Can nanoparticles and other pollutants have connections with Alzheimer's?

Can nanoparticles and other pollutants have connections with Alzheimer's?

"Purdue researchers have uncovered how fat-laden immune cells in the brain fuel Alzheimer’s. Credit: Shutterstock" (ScitechDaily, New Research Overturns Decades of Thinking on Fat’s Role in Alzheimer’s)

"For many years, scientists believed that fat in the brain had little connection to neurodegenerative diseases. Purdue University researchers are now challenging that view." (ScitechDaily, New Research Overturns Decades of Thinking on Fat’s Role in Alzheimer’s)

"Their study, published in Immunity, demonstrates that an accumulation of fat in microglia, the brain’s immune cells, weakens their disease-fighting capacity. The discovery points toward new therapeutic strategies in lipid biology that could support microglial activity and improve neuronal health in conditions such as Alzheimer’s. The work was led by Gaurav Chopra, the James Tarpo Jr. and Margaret Tarpo Professor of Chemistry and (by courtesy) of Computer Science at Purdue." (ScitechDaily, New Research Overturns Decades of Thinking on Fat’s Role in Alzheimer’s)

Researchers noticed. There is a connection between Alzheimer’s and nanoplastics. There is a possibility that pollutions simply block small blood vessels in the brain. And that causes a situation where dirt starts to accumulate in those blood vessels. That thing can decrease and block nutrients. From cells that those small capillaries should feed. 

So could the nanoparticles cause Alzhemers's in the same way as smoking cigarettes causes coronary artery disease? In those cases, nanoparticles simply block the coronary arteries. That causes. The heart and its muscles don’t get enough nutrients and oxygen. This can explain why alcoholism also causes those diseases. Alcohol dissolves fat that will suck in blood vessels. And that can cause heart attacks and also things like Alzheimer’s. Alcohol also dissolves proteins from the myelin cells’ shells. And that lets dangerous plaque move between those cells. That plague can jam the myelin cell’s ability to take nutrients by blocking its ion pumps. 

If the blood vessels are jammed, that means the cells that the blocked blood vessel feeds get without nutrients. When we think about Alzheimer’s, there is a possibility that the microplastics can be stuck in the small blood vessels in the brain. Those microplastics cause a point to form in the blood vessels. That starts to accumulate impurities at that point. That means Alzheimer’s can be similar to coronary artery disease. Some kind of dirt in the blood vessels blocks them. And if that happens in the blood vessels. That feeds brain cells. That decreases those cells’ ability to get nutrients and oxygen. This decreases their ability to accomplish their mission. 

"A University of Rhode Island study suggests micro- and nanoplastics can accumulate in the brain, potentially accelerating Alzheimer’s symptoms in genetically at-risk individuals. Credit: Stock". "(ScitechDaily, Microplastics May Trigger Alzheimer’s-Like Brain Damage)

The reason why nanoparticles can have a connection with Alzheimer’s is simple. Those particles can block the smallest blood vessels in the brain. When blood flow in those small blood vessels slows or becomes difficult, this can cause an effect. Immune cells cannot reach all areas of the brain. And that causes the accumulation of the plague. The model goes like this. In normal brains, blood vessels are large enough. The immune cells reach all brain areas. Their mission is to remove zombie cells and other things. And if immune cells have no access to all brain areas, that forms blocks and plaques in those areas. 

Like metabolic waste that cells form in metabolism. Even if neurons are well protected against infections. The myelin cells that feed neurons are where Alzheimer’s forms. Things like sniffing glues cause situations where there are holes in the myelin structure. And then the plague can slip through this protective muzzle.  Some of those holes can also form, if the myelin cell turns overage. 

Another case is that the small particles can cause Alzheimer’s. Because those particles don’t allow the immune cells to clean the farthest points in the smallest blood vessels. If things like fullerene slip into the blood vessels, those things form bubbles in the blood plasma. And those ball-shaped carbon molecules can also slip into the cells, and if there is some kind of acoustic effect that puts the fullerene into oscillation, that oscillation forms millions of bubbles in the blood vessels. 

Those bubbles can jam the blood flow. Or they can destroy the immune system’s cells. They can affect another cell type’s internal structure. If small particles. Slipping into the myelin cells, it can cause a situation where the cell cannot get enough nutrients.  In the same way. If the cell that transports nutrients is filled with bubbles, that means it cannot carry enough nutrients to the cells. 

Bubbles are always dangerous, because they can decay. When the oscillating membrane pulls the bubble larger, that causes an effect where a low-pressure area forms around that bubble. The low-pressure area causes a situation where a small part of the fluid boils. And that effect forms more bubbles. When there are enough bubbles in some blood vessels, they simply block those vessels. 

https://scitechdaily.com/microplastics-may-trigger-alzheimers-like-brain-damage/

https://scitechdaily.com/new-research-overturns-decades-of-thinking-on-fats-role-in-alzheimers/

The artificial immune system can be a revolution in medical research.

"Georgia Tech researchers developed lab-grown models of human immune systems, called immune organoids, to study immune function in cancer patients and improve vaccine development. These synthetic hydrogels mimic immune environments, enabling precise studies of immune vulnerabilities, particularly in lymphoma survivors, and fostering innovative treatments." (ScitechDaily, Miniature Lab-Grown Immune Systems Could Transform Cancer Treatment Research)

Fighting against things like cancer is quite an easy thing, theoretically. The problem is how to detect those cells in the human body. In the cases where the immune system's stem cells cause cancer is possible to destroy the bone marrow from bones. 

Then the cleaned bone marrow will be injected back into the human body. The problem is how to destroy the cancer genomes from the stem cells. One of the possibilities is to detect cancer genomes from the DNA and then remove those base pairs. And then. It can inject that cleaned DNA back into those stem cells. 

The AI can replace traditional genome tests. The AI can read the DNA using scanning photonic or tunneling microscopes. Because. A morphing neural network can start the operation in many points of the DNA at the same moment. That system can analyze DNA in a very short time. Then the system can cut the DNA in the wanted points. The nanotechnical system removes non-wanted base pairs from the DNA and replaces them with the right base pairs. Then that system can inject fixed DNA into the stem cells. 

A lab-grown immune system is a tool. That can test medicines and viruses. That system can also used in cases. Where the natural immune system is falling. Researchers can teach or program the lab-grown immune system and then inject those immune cells into the human body. That thing can increase the immune system's ability to fight against infections and cancer. 

The programmed artificial immune cells can destroy the bacteria or other non-wanted cells in the body. Then the programmed DNA can change its form. Those cells would destroy their structure and turn themselves into slime balls, that have chemical marks that the body removes those cells. 

The genetically engineered cells can be used to mark tissues for the immune cells. They can used to identify zombie cells from the human body. But genetic engineering allows to creation of immune cells that live only a short time. That kind of genetically engineered immune cells can collect viruses from the blood and then remove them. 

In some versions, the system removes all immune cells from the body if there are problems with them. Then the system can inject the new genetically engineered immune cells and their stem cells into the patient's body. 

The ability to create artificial cells is a big breakthrough in biotechnology. The manipulated and genetically engineered cells can remove bacteria and so-called zombie cells from the body. They can remove toxic waste from the body, and when those genetically engineered cells can die or change their form. Genetic engineering is a tool that has unlimited abilities. The threats of genetic engineering are also big. 

When we think about the terms biomanipulation and genetic engineering we must realize that those things are not the same. 

In biomanipulation, the developers manipulate the environment or nutrients. And then they change the behavior of the cells or other organisms. One of the best examples of those things is mice or rats that get heroin or some other drugs. Then the officials equip them with GPS and then free those rodents into parks. That thing makes it possible to track drug caches from the area. 

In genetic engineering, developers change the DNA or mRNA structure to change the organism's shape and behavior. Genetic engineering allows the developers to remove hereditary diseases by removing harmless parts of the DNA and then injecting that DNA back into the morula. That method requires complete knowledge of genomes. 

In those cases, the system just removes the sick DNA and replaces that thing with new DNA. That allows one to change cells into another. That methodology allows researchers to make genome transplants into single cells. But the problem is in cases where a large number of cells will be manipulated. 

The artificial immune system can be the base for technology, where genetically engineered cells will transfer genetic material into the entire body. The manipulated cells produce artificial viruses that they inject into the cells that the staff wants to manipulate. Artificial mRNA viruses are tools for next-generation vaccines. 

The next-generation immune therapy is based on the mRNA that can order cells to destroy themselves. The problem is how to transfer the mRNA that orders the cell to make suicide to the precisely right cells. In wrong cell groups, those things can cause large-size damage or even kill the patient. The limits of genetic engineering are in the minds of people. The same things that can give treatment can kill targeted people. And that means that thing is a destructive tool for the military. 

https://scitechdaily.com/blood-becomes-medicine-in-a-revolutionary-regeneration-breakthrough/

https://scitechdaily.com/new-harvard-developed-ai-system-unlocks-biologys-source-code/

https://scitechdaily.com/miniature-lab-grown-immune-systems-could-transform-cancer-treatment-research/

https://scitechdaily.com/synthetic-evolution-genetically-minimal-artificial-cells-prove-life-finds-a-way/